The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and marginally soluble in alcohol. The molecular weight is 406.37. Its molecular method is C18H21NO3•H3PO4 • ½ H2O, and it's got the subsequent chemical framework.
Aspirin cannot be taken by small children beneath the age of sixteen several years, simply because there is a pretty modest possibility of the child developing a significant ailment identified as Reye's syndrome.
Codeine is usually a form of opioid, a drug course that features impressive painkillers like morphine and oxycodone. Derived from the opium poppy plant, codeine operates by transforming how the brain and nervous procedure respond to pain and coughing [2].
Shallow breathing: In larger sized doses, codeine slows down respiratory. This is one of the major triggers of overdose.
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One example is, several noted cases of Dying happened in the publish-operative period following tonsillectomy and/or adenoidectomy, and plenty of of the children had evidence of currently being extremely-swift metabolizers of codeine. Moreover, children with obstructive snooze apnea who are handled with codeine for submit-tonsillectomy and/or adenoidectomy pain might be particularly sensitive to its respiratory depressant result. Because of the risk of lifetime-threatening respiratory melancholy and Dying:
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If Promethazine HCl and Codeine Phosphate Oral Solution is used for a chronic period inside a pregnant woman, recommend the affected person of the chance of neonatal opioid withdrawal syndrome and make sure that ideal procedure will be accessible [see Warnings and Safety measures (five.20)].
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As a result of hazard of respiratory depression, stay clear of using opioid antitussives, together with Promethazine HCl and Codeine Phosphate Oral Resolution in patients with compromised respiratory function, clients prone to respiratory failure, As well as in elderly, cachectic, or debilitated sufferers.
The concomitant use of Promethazine HCl and Codeine Phosphate Oral Alternative with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may possibly result in decreased codeine concentrations, increased norcodeine amounts, and less metabolism by using 2D6 with resultant decreased morphine ranges.
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